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Inflammation & Systemic Stress
-Treatment with Magnesium Chloride

Source: Mark Sircus Ac., OMD

Obesity without inflammation
does not result in insulin resistance.
Dr. Jerold Olefsky

Inflammation plays a key role in a set of disorders that include
type II diabetes, obesity, and heart disease—collectively called the
metabolic syndrome. Dr. Steve Shoelson, a professor of medicine at
Harvard Medical School has focused squarely on inflammation.
Epidemiologists have found that patients with type 2 diabetes and
cardiovascular disease have slightly elevated levels of inflammatory
markers in their bloodstream, raising the possibility that
inflammation might be associated with the development of these
diseases, and proinflammatory cytokines such as TNF-a and IL-6 promote
insulin resistance in experimental models.

Inflammation itself has been well studied by immunologists: after
an infection, a host of different types of immune cells are deployed
to the infection site to control the infection. But Dr. Shoelson says
that the situation is different in patients with metabolic diseases:
the same markers of an immune response are present, but they persist
chronically at a low levels instead of following the dramatic rise and
fall in an infection.

Inflammation has been shown to be linked to insulin resistance and
to defective insulin signaling in nonobese diabetic (NOD) mice.

Several years ago, Shoelson’s team was studying mechanisms
underlying insulin resistance—the failure of the body to respond to
its own insulin, a condition that raises blood sugar and can lead to
diabetes. They found reports from more than a century ago that high
doses of anti-inflammatory medications called salicylates lowered the
blood sugar levels of patients with diabetes.

Medicine does not recognize how subtle, constant and easily
triggered inflammatory processes can be. “Eating induces an
inflammatory state in everyone. Normally, inflammation occurs for
three or four hours after eating but will then taper off. Though
people can't avoid eating, Dr. Dandona says they can avoid what and
how much they eat. He says, "If people eat McDonald's-type meals every
three or four hours, and many do, they spend most of their time in a
pro-inflammatory state."

“Inflammation in blood vessels is one of the main drivers of
atherosclerosis, and diabetes makes it much worse,” said Dr. Jun-ichi
Abe of the University of Rochester Medical Center. Dr. Abe said that
in people without diabetes, fast blood flow triggers anti-inflammatory
enzymes, endothelial nitric oxide synthase and other factors, which
block the ability of pro-inflammatory immune cells to home in on and
adhere to diseased portions of blood vessels.

A study, also published in March of 2008, was done at New York
University, has found that pregnant women with periodontal (gum)
disease have an increased risk of developing gestational diabetes
mellitus than pregnant women with healthy gums. Again we see
inflammation in diabetes with the inflammation of the gums spreading
to the rest of the body through the blood vessels.

Inflammation plays a pivotal role in all stages
of atherosclerosis, which is the progressive
narrowing and hardening of the arteries over time.

Inflammation is the activation of the immune system in response
to infection, irritation, or injury. Characterized by an influx of
white blood cells, redness, heat, swelling, pain, and dysfunction of
the organs involved, inflammation has different names when it appears
in different parts of the body. Most allergy and asthma sufferers are
familiar with rhinitis (inflammation of the nose), sinusitis
(inflammation of the sinuses), and asthma (inflammation of the
airways), but inflammation is also behind arthritis (inflammation of
the joints), dermatitis (inflammation of the skin), and so on.

The inflammatory response can be acute or chronic. Acute
inflammation typically lasts only a few days. This response usually
promotes healing but, if uncontrolled, may become harmful.

The primary objective of acute inflammation is to localize and
eradicate the irritant and repair the surrounding tissue but this
completely changes in chronic low-grade inflammatory states. Chronic
low-grade inflammation is one of the characteristics of the metabolic
syndrome and interferes with insulin physiology. Ignorance has
prevailed over the interrelationship between muscular lipid
accumulation, chronic inflammation and insulin resistance because the
central mediating factor is magnesium. It is magnesium that modulates
cellular events involved in inflammation.

There are many factors that trigger inflammation. They are found
in both our internal and external environments and include excessive
levels of the hormone insulin (insulin resistance), emotional stress,
environmental toxins (heavy metals), free-radical damage, viral,
bacterial, fungal other pathogenic infections, obesity, over
consumption of hydrogenated oils, periodontal disease, radiation
exposure, smoking, spirochetes such as the Borrelia that causes Lyme
disease, and certain pharmacological drugs. Problems with insulin
metabolism are a major contributor to cardiovascular disease. It
results in the inability to properly store magnesium, causing blood
vessels to constrict, elevated blood pressure, and coronary arterial
spasm, all of which can result in a heart attack.

Excess insulin causes retention of sodium, fluid retention,
elevated blood pressure and congestive heart failure.

Dr. Ron Rosedale

Inflammatory reactions in the body are a valuable predictor of
impending heart attack. Dr. Robert Genko, editor of the American
Academy of Periodontal Journal, claims that persons with gingival
disease (which is an inflammatory disorder) are 27 times more likely
to suffer a heart attack than are persons with healthy gums. An
American Heart Association paper disclosed that 85% of heart attack
victims had gum disease compared to 29% of healthy similar patients.

When magnesium levels of fall researchers note a
profound increase of inflammatory cytokines
present, along with increased levels of histamine.

Magnesium deficiency causes and underpins chronic inflammatory
build ups. This concept is intriguing because it suggests a
fundamentally simpler way of warding off disease. Instead of different
treatments for heart disease, Alzheimer's and colon cancer, we apply a
single, inflammation-reducing remedy that would prevent or treat these
and other deadly diseases. The key words here are ‘prevent’ or ‘treat’
but please notice the word is not cure. Though magnesium is a cure for
many of our ailments full treatment protocols are recommended with
magnesium chloride as the top protocol item. It is a protocol of basic
items like magnesium, iodine, Alpha Lipoic Acid, sodium bicarbonate,
sodium thiosulfate, whole food vitamin C, natural vitamin D from the
sun, spirulina and some other important items like purified water that
will make a difference in a host of chronic diseases.

Once we understand the critical importance of
inflammation and glutathione depletion in brain diseases,
we can take steps to prevent or even reverse the damage.

Dr. David Perlmutter

Inflammation and systemic stress are central attributes of many
pathological conditions. In magnesium we have found a potent medicinal
that is effective across a wide range of pathologies. Pharmaceutical
companies need look no further then the sea shore, which contains
millions of tons of magnesium chloride the perfect anti-inflammatory

Is your heart on fire?
New York Times

It could very well be but we most likely will not know it until
we suddenly have cardiac arrest. Researchers recognize a silent kind
of inflammation. This type of internal inflammation has an insidious
nature and is the culprit behind diabetes and heart disease. The
chronic and continuous low-level stress that silent inflammation
places on the body's defense systems often results in an immune-system
breakdown. Magnesium deficiency is a parallel silent insult happening
at the core of our physiology. Magnesium deficiencies feed the fires
of inflammation and pain.

Epidemiologic studies have shown an inverse relationship between
magnesium in the drinking water and cardiovascular mortality. This
association between magnesium in drinking water and ischemic heart
disease was reconfirmed in a major review of the literature done by
epidemiologists at Johns Hopkins University. Since most heart disease
is marked by various levels of inflammation these studies were all
highlighting the hidden relationship between inflammation and
magnesium deficiency.

Another reason that chronic inflammations can take
us into the hell fires of pain is that magnesium
gets depleted in conditions of inflammation.

Beyond all the common symptoms of inflammation we find the body
tissues themselves may lose their ability to recognize cells that are
"self " from those that are not, and the body may mistakenly identify
its own cells as foreign invaders. This internal programming error
then continues to trigger and retrigger immune responses, setting the
stage for autoimmune diseases, such as lupus, multiple sclerosis, and
scleroderma. The result is cellular chaos, and what is even more
disturbing is that this process may be happening year after year
without our even being aware of it.

This chronic inflammatory response breaks down healthy
tissue in a misdirected attempt at repair and healing.

Doctors who specialize in rheumatoid arthritis, multiple
sclerosis, lupus and other autoimmune disorders are very familiar with
what happens when the body goes to war with itself. These diseases
demonstrate a direct inflammatory attack against healthy cells in such
places as the joints, nerves and connective tissue.

Magnesium is central to immunocompetence and plays
a crucial role in natural and adaptive immunity.

Alzheimer's patients who were already taking
anti-inflammatory drugs for arthritis or heart disease
tend to develop the disorder later than those who weren't.

Atherosclerosis is caused by chronic inflammation, which often
begins very early in life. The big dispute among experts is what
causes the inflammation in the first place. One theory holds that
bacteria and viruses may cause this inflammation but clearly we know
that lead, mercury, monosodium glutamate (MSG) and fluoride and other
toxic chemicals can also cause inflammatory reactions in blood

Recent advances in the field of cardiovascular
medicine have emphasized the involvement of
inflammation in the formation of atherosclerotic plaque.

This chapter represents basic research into the nature of
inflammation. It looks beyond the pharmaceutical companies; beyond
aspirin and other multipurpose experimental drugs that block
inflammation, but not without collateral damages. Magnesium is at the
heart of the inflammatory process, it is the prime first cause when it
is not present in sufficient quantities. Increases in extracellular
magnesium concentration cause a decrease in the inflammatory response
while reduction in the extracellular magnesium results in
inflammation. Inflammation causes endothelial dysfunction and
activated endothelium facilitates adhesion and migration of cancer

Chronically inflamed tissues continue to generate signals that attract
leukocytes from the bloodstream. When leukocytes migrate from the
bloodstream into the tissue they amplify the inflammatory response.

Magnesium literally puts the chill on inflammation especially
when used transdermally. Heart disease begins with inflammatory
chemicals that rage like a fever through your blood vessels. Cool the
heat by getting the recommended daily minimum of magnesium suggests
Medical University of South Carolina researchers. They measured blood
inflammation levels--using the C-reactive protein (CRP) test--in 3,800
men and women and found that those who got less than 50% of the RDA
(310 to 420 mg) for magnesium were almost three times as likely to
have dangerously high CRP levels as those who consumed enough. Being
over age 40 and overweight and consuming less than 50% of the RDA more
than doubled the risk of blood vessel-damaging inflammation.

The magnesium intake of a total of 11,686 female health
professionals who were younger than 45 years old and had not had heart
and blood vessel disease, a stroke, or cancer was studied in 2005 by
Dr. Y. Song and collegues.8 Prior to this only a few studies have
been done to see whether magnesium intake is related to inflammation
in the body. The researchers wanted to know if women who have more
magnesium in their diet or take magnesium supplements had a lower risk
of inflammation and the metabolic syndrome.

Women who got more magnesium in their diet were less likely to
have the metabolic syndrome, inflammation in the body, and heart and
blood vessel disease. Inflammation in the body was less common in
women who got more magnesium. Women who had the highest magnesium
intake had 12% lower C-reactive protein levels than women with the
lowest magnesium intake. This study shows that the magnesium found in
a healthy, well-balanced diet can protect the body against
inflammation and high blood glucose, conditions that can lead to type
2 diabetes and heart and blood vessel disease.

Chronic inflammation destabilizes cholesterol deposits in
the coronary arteries, leading to heart attacks and strokes.

A study performed by the VA Administration, published in JADA,
1998 on 10,000 US veterans, showed that most coronary heart disease
started as an endothelial infection and in most cases was caused by
pathogens. Recognizing the role of inflammation in arteriosclerosis
represents a huge paradigm shift for cardiologists. The American
College of Cardiology, the American College of Physician's and the
American Heart Association largely ignores the involvement of
inflammation in heart attacks and strokes and certainly they ignore
unresolved psycho-emotional trauma, as well as the toxic build up of
mercury which can lead to massive heart failure and sudden death even
in the healthiest athlete.

Inflammation not only further damages the artery walls, leaving
them stiffer and more prone to plaque buildup, but it also makes
any plaque that's already there more fragile and more likely to burst.

A 2006 issue of the Journal of the American College of Nutrition
an article showing that as consumption of magnesium fell, the levels
of C-reactive protein went up. C-reactive protein, or CRP, is produced
in the liver and has emerged as a strong predictor of clinical events
of cardiovascular diseases, such as heart attacks and stroke, even in
cases where cholesterol levels may be normal. For this reason, CRP
assays may become a routine part of blood tests for determining CVD
risk. CRP levels in the blood are normally undetectable or very low;
high levels are strongly associated with inflammation.

Inflammation is the missing link to explain the
role of magnesium in many pathological conditions.

Persistent asthma is an inflammatory disease that requires
regular anti-inflammatory therapy with magnesium chloride.

This new view of inflammation is changing the way some doctors’
practice but most cardiologists are still not ready to recommend that
the general population be screened for inflammation levels.
Cardiologists don’t know it but when in rare instances they test for
serum magnesium levels they are not measuring anything but strictly
controlled magnesium levels in the blood. There continues to be a
blind spot the size of the Gulf of Mexico in cardiologists’
perceptions. They just are not able to get to the bottom of the
inflammation story – which is magnesium deficiency.

Magnesium decreases swelling, and, "is effective
in the treatment of inflammatory skin diseases.

Scientists at the Joslin Diabetes Center in Boston, have bred a
strain of mice whose fat cells are supercharged inflammation
factories. "We can reproduce the whole syndrome (diabetes) just by
inciting inflammation," Dr. Steve Shoelson says. This suggests that a
well-timed intervention in the inflammatory process might reverse some
if not all the effects of diabetes. Some of the drugs that are already
used to treat the disorder, like metformin, may work because they also
dampen the inflammation response. In addition, preliminary research
suggests that high CRP levels may indicate a greater risk of diabetes.

Whatever makes us become less efficient at using insulin is
going to aid in the development of diabetes. Treatments for
diabetes work by replacing insulin, boosting its production
or helping the body make more efficient use of the hormone.

Modern medicine is just starting to admit that chronic
inflammation is the main contributing factor to heart disease and it
is just about to discover magnesium chloride as a supremely safe and
effective anti inflammatory. Magnesium chloride safely reduces
inflammation and systemic stress because magnesium deficiencies are in
great part the cause of both conditions.

People with magnesium deficiency can't properly metabolize important
fatty acids such as EPA and DHA, which are vital to heart health.

There are literally hundreds of physiological reasons to proclaim
magnesium the ultimate heart medicine; its involvement in hundreds of
enzyme reactions is just a start. Its use as an anti inflammatory
makes magnesium absolutely indispensable to not only heart patients
but also to diabetics, neurological and cancer patients as well. The
treatment of chronic inflammation has been problematic for medical
science because most of their treatments create more inflammation.
Magnesium chloride does not do this, especially when applied
transdermally. Transdermal magnesium therapy is the ultimate medical
treatment for inflammation and pain.

Magnesium Oil can be applied directly to inflamed areas.

Transdermal Magnesium Therapy offers an important breakthrough in
medical treatment offering an excellent a form of magnesium
supplementation that is just not possible with oral use alone.
Transdermal medicine is ideal for pain management as well as sports
and pediatric medicine and for diabetic neuropathy there is nothing
better in the entire world of medicine.

Traditional methods of administering medicine such as tablets or
capsules get watered down and become much less effective due to
stomach acids and digestive enzymes, before they eventually get into
the bloodstream. Bypassing the stomach and liver means a much greater
percentage of the active ingredient goes straight into the bloodstream
where it’s needed and in the case of neuropathy medicinal properties
are concentrated in the local tissues.

Drugs enter different layers of skin via intramuscular,
subcutaneous, or transdermal delivery methods.

Imagine receiving your medical treatment right in the comfort of
your own home if you cannot get to the warm sea water.

Transdermal magnesium therapy is ideal for pain management,
diabetic neuropathy and inflammation. The combination of heat and
magnesium chloride increases circulation and waste removal.The
therapeutic effect of magnesium baths is to draw inflammation out of
the muscles and joints. Magnesium chloride, when applied directly to
the skin is transdermally absorbed and has an almost immediate effect
on pain.

What better way to reduce or eliminate pain then by simply taking
a therapeutic bath or rubbing magnesium chloride substance in liquid
form directly onto the skin or affected area of the body? From the
pain of sports injuries to low back pain and sciatica, headaches,
relief from kidney stones, the pain of restless legs, arthritic pain,
and just about every painful condition imaginable will in all likely
hood benefit from medicines applied topically.

Virtually all the components of the Metabolic Syndrome
of diabetes, high blood pressure, obesity and lipid
disorders are associated with low magnesium.

Dr. Michael R. Eades

Dr. Eades insists that theentire Metabolic Syndrome is nothing
but a manifestation of a magnesium deficiency. This is not an
exaggeration but in my soon to be announced book New Paradigms in
Diabetic Care we will uncover keys like mercury poisoning as well as
fungal infections in addition to this important inflammation story
that combine to destroy our metabolic functions. In three books now I
have written about the magnesium story and about how, when deficient,
just about everything that can go wrong in human physiology does. In
the diabetes book I also examine calcification issues, raw food and
low carbohydrate diets, vitamin D and magnesium deficiencies and the
use of magnesium chloride (transdermally and orally administered),
sodium bicarbonate, sodium thiosulfate, alpha Lipoic Acid and many
other things that will mean a world of difference to the crumbling
metabolic function of a great part of the human race.

Dr. Eades asks, “Why are so many people deficient in magnesium?
Because there are no single foods that contain huge amounts of
magnesium, and because there is no single food containing large
amounts, there is no magnesium lobby. Look at calcium. Thanks to the
dairy industry, we are constantly told that we need to get enough
calcium, and we’re told right where we can get it. Milk and cheese.
Same with vitamin C. The orange juice people never let us forget. Not
so with magnesium, so no one really thinks of it. Another reason that
many people are magnesium deficient is that they drink bottled water
or softened water. In the old days everyone drank well water or water
from streams, both of which contain large amounts of magnesium.
Magnesium is removed when water is softened and it isn’t in large
amounts in most of the bottled waters that are available.”

Inflammation contributes to the pro-atherogenic changes in
lipoprotein metabolism, endothelial dysfunction, thrombosis,
hypertension and explains the aggravating effect of magnesium
deficiency on the development of metabolic syndrome.

Dr. Andrzej Mazura

Dr. Andrzej Mazur, et. al.1 have shown in experimentally induced
magnesium deficiency in rats that after only a few days a clinical
inflammatory syndrome develops and is characterized by leukocyte
(white blood cell) and macrophage activation, release of inflammatory
cytokines and excessive production of free radicals. “Magnesium
deficiency induces a systemic stress response by activation of neuro
endocrinological pathways,” writes Dr. Mazur. “Magnesium deficiency
contributes to an exaggerated response to immune stress and oxidative
stress is the consequence of the inflammatory response,” he continued.

Long-term air pollution exposure is associated with
neuroinflammation, an altered innate immune response, disruption of
the blood-brain barrier, ultrafine particulate deposition, and
accumulation of amyloid beta-42 and alpha-synuclein in children and
young adults.

Magnesium-deficient rats develop
a generalized inflammation.
Dr. Sophie Begona

It turns out that statins don't just lower cholesterol levels;
they also reduce inflammation.The lipid hypothesis of heart disease is
rapidly being supplanted by the inflammatory hypothesis. The
researchers who have spent their careers doing cholesterol research
are falling further and further into disfavor as most scientists are
showing graphs demonstrating that elevated cholesterol in combination
with an elevated C-reactive protein is a better gauge of heart disease
risk. It seems that without the inflammation elevated cholesterol is
not a threat after all.

Today the most prescribed of all are drugs is used to lower "bad"
LDL cholesterol. For those who are still interested in the cholesterol
connection niacin (vitamin B-3) in high doses is as effective, much
cheaper, and most importantly, far safer then any drug.4 Niacin also
dramatically lowers triglycerides. The New York Times said, "An
effective HDL booster already exists. It is niacin, the ordinary B
vitamin. Niacin can increase HDL as much as 35 percent when taken in
high doses, usually about 2,000 milligrams per day . . . and it has
been shown to reduce serum levels of artery-clogging triglycerides as
much as 50 percent."

Inflammation is a response from your immune system in response
to an irritant. For example, if you sprain your ankle, your immune
system creates a protein called a Circulating Immune Complex (CIC for
short). The CIC travels down to the injured ankle and causes pain and
swelling. The pain you feel is to inform you of the injury or damage.
And the swelling is protective as it prevents you from moving it and
causing more irritation. This is also your body's way of running to
the problem with fresh blood, antibodies and vital cells in order to
begin healing and repairing the damage.

Then what normally happens is our bodies produce proteolytic
enzymes which counteract the inflammation, and things return to
normal. That's why a sprained ankle as a young child heals within a
few weeks at most, but can take six weeks or more for an adult of say
45. The problem is, after around age 25, our production of these
enzymes drops off almost completely so there is nothing to tell the
body to stop the inflammation. These enzymes are also responsible for
cleaning the blood, fighting off viral and bacterial infections and
breaking down excess fibrin (scar tissue). Most if not all of these
enzymes are mediated by magnesium meaning as magnesium levels drop off
so do the activities of these crucial biological magnesium sensitive

Enzymes break down scar tissue and fibrosis. Fibrosis is scar
tissue that builds up in our bodies and over time creates some much
restriction and strain on our organs that they can no longer function
properly. Enzymes also clean the blood of excess fibrin that causes
the blood to thicken, which sets us up for clots, which can cause
heart attack or stroke. Enzymes also help take some of the strain off
of the liver by keeping the blood clean and not allowing it to thicken
beyond normal. Enzymes are very important in inflammation and enzymes
bring us back to their fundamental supporter, which is magnesium.

When I received the following account from my research assistant
Claudia French, who is an RN in an acute care psychiatric hospital, I
realized that we should address the issue of magnesium, inflammation
and pain more directly.

Yesterday I witnessed one of the most amazing benefits of transdermal
magnesium I have seen. I work with another RN who is afflicted with
arthritis, especially in her hands, and frequent muscle
cramping/spasms in her legs. She has been using magnesium but became
lax. Before leaving for work yesterday I received a phone call from
her begging me to please bring with me some magnesium oil, as her
hands were so cramped up and painful that she could barely stand to
continue working.

When I got there, her hands and fingers were very contorted in spasm.
Her fingers were curled up and stiff and her legs were cramping badly.
She reported they had been this way all day, and the pain was driving
her to tears. She immediately slathered the magnesium oil all over her
hands. We were in report and she wanted it on her hands right away so
the entire nursing staff watched and within 5 minutes you could
visibly see her fingers extend back to normal and the finger movement
return. We could literally see the relaxation taking place. It was
simply amazing. Within minutes her hands were completely relaxed and
functional again and stayed that way the remainder of the evening.
She also applied the magnesium to her legs and found relief.
About 30 minutes after applying the oil, she held up her hands for
everyone to see, and showed us the arthritic nodules on some fingers.
She described how painful these always are to touch. But she poked
and prodded them telling us how there was no pain now. She was able to
continue working and doing the extensive writing that is a large part
of our work without any further discomfort.

Pain relief and muscle relaxation for people with arthritis and
muscle cramping is an important and significant benefit of magnesium
oil. The rapid relief, visible to us all was really amazing! The
following day she reported that she’d gotten the first restful night
of sleep in many days. The pain was not waking her up.

Principles and Practices of
Transdermal Medicine

Transdermal medicine delivers
medications to the exact site of injury/pain.

Transdermal medicine is ideal for pain management as well as
sports and pediatric medicine. In fact it is one of the best ways of
administering medicines quickly and effectively. Transdermal methods
of delivery are widely used because they allow the absorption of
medicine directly through the skin. Gels, emulsion creams, sprays and
lip balm stick applicators are easy to use and are effective in
getting medicine into the blood stream quickly.

Transdermal delivery of medicines is generally considered safer,
more efficient, more convenient and less painful than injections or IV’s.

Transdermal magnesium therapy in particular offers an exciting
breakthrough in sports medicine. Coaches can now treat injuries,
prevent them, and increase athletic performance all at the same time.
Transdermal magnesium chloride mineral therapy enhances recovery from
athletic activity or injuries. It reduces pain and inflammation while
propagating quicker regeneration of tissues. Topical application of
magnesium chloride increases flexibility, which helps avoid injury. It
also increases strength and endurance. Transdermal Magnesium Therapy
is a boon for athletes, coaches and doctors who practice sports

The concentration of the applied dose, the surface area of the
body, and the elapsed time the chemical is on the skin are the main
considerations affecting absorption. As the concentration of a drug
is increased, the total amount absorbed into the skin and body also
increases. Increasing the surface area of the applied dose also
increases penetration.

Penetration occurs over time. The longer the substance is on the
skin, the greater the chance for continued penetration. The total
amount of a drug absorbed during a 24-hour period may be different for
a single application as opposed to the same amount applied in divided
doses. In other words, applying a medicine once a day in the morning
delivers a different concentration as opposed to applying a medicine 3
times a day 8 hours apart.

Herbal poultices, therapeutic baths, steam and dry saunas,
transdermal patches, transdermal magnesium and transdermal iodine
therapy rely on the permeability of the skin for either introducing
substances into systemic circulation via the skin or mucous membranes,
or for drawing toxic substances out of the system via the eliminative
channels of perspiration.

When using transdermal medicines one has to be aware that:

Applying more of a substance
increases the amount absorbed.

One also has to be aware of the purity of the product one is
putting on ones skin since the impurities are also absorbed. The
purest magnesium oil I have found comes from deep underground in
Europe from a 250 million year old trapped sea. Ancient Minerals has
my full product endorsement and I am just testing out their new gel
product and find it excellent for treating severe back conditions.

Magnesium Massage is one of the ultimate hands on treatments for
body workers as well as Chiropractors and Osteopaths. Anything one
does to the body with ones hands is enhanced when you put magnesium
oil or gel onto the body. Magnesium oil turns a casual massage into a
medical treatment that is super relaxing as it is therapeutic.

What is essential to remember about treating pain with magnesium is
that it treats both the symptom and the cause of pain. Meaning the
cause of the pain can often be traced back to a magnesium deficiency.

There are not too many medicinal substances or medicines that
can make this claim. It should be noted that pain management with
magnesium employs magnesium chloride applied transdermally to the
skin. Dr. Linda Rapson, who specializes in treating chronic pain,
believes that about 70 per cent of her patients who complain of muscle
pain, cramps and fatigue are showing signs of magnesium deficiency.
"Virtually all of them improve when I put them on magnesium," says
Rapson, who runs a busy Toronto pain clinic. "It may sound too good to
be true, but it's a fact." She's seen the mineral work in those with
fibromyalgia, migraines and constipation. "The scientific community
should take a good hard look at this."

Lynne Suo is one of Dr. Rapson’s patients. She had been using
painkillers and steroids for years to try to ease the pain of her
arthritis and fibromyalgia. Dr. Rapson started her on 675 units of
magnesium a day. Within days, Suo called Dr. Rapson to report a
surprising change. "I went from being in constant pain almost
throughout the day and night to having moments of pain. And for me
that was a huge improvement," says Suo, a former college English
teacher. She dismisses suggestions that the change is a placebo
effect. "I was not one day without pain and now I don't have to take
heavy pain medication," she reports.

The granddaddy of all anti-inflammatories is aspirin, which can
cause more serious problems than it can alleviate. Most pain and
anti-inflammatory medications are not safe; even the over the counter
pain medications hold unforeseen dangers. Despite more than a decade's
worth of research showing that taking too much acetaminophen can ruin
the liver, the number of severe, unintentional poisonings from the
drug is on the rise, a new study reports.2 The drug, acetaminophen, is
best known under the brand name Tylenol. Compounds containing Tylenol
include Excedrin, Midol Teen Formula, Theraflu, Alka-Seltzer Plus Cold
Medicine, and NyQuil Cold and Flu, as well as other over-the-counter
drugs and many prescription narcotics, like Vicodin and Percocet.

People with poor quality sleep or sleep deprivation exhibit
increased levels of interleukin-6 (IL6), the chemical that causes
inflammation throughout the body. According to Dr. J. Durlach, the
biological clock and magnesium status are linked, and a balanced
magnesium status is important for the function of the mysterious
pineal gland. Dr. Durlach sees the psycholeptic sedative effects of
darkness amplified by magnesium. There probably is a strong
relationship between melatonin and magnesium; certainly relative
amounts of light and darkness affect the pineal gland and its
production of melatonin. Magnesium provides a calming effect that
allows for deeper relaxation and better sleep. Magnesium is considered
the "antistress" mineral. It is a natural tranquilizer which functions
to relax skeletal muscles as well as the smooth muscles of blood
vessels and the gastrointestinal tract.

According to the National Sleep Foundation approximately 70
million people in the United States are affected with sleeping
disorders. Approximately 12 million Americans have restless legs
syndrome, a sleep and movement disorder characterized by unpleasant
(tingling, crawling, creeping and/or pulling) feelings in the legs,
which cause an urge to move in order to relieve the symptoms.
Magnesium supplements may be helpful for relieving restless leg
syndrome (RLS) and for treating insomnia.

Depression also is correlated with inflammation. A study
conducted by researchers at the Emory University School of Medicine
found that psychological stress leads to an excessive inflammatory
response in people. Their findings published in the American Journal
of Psychiatry showed that individuals who suffer from depression are
more likely develop an inflammatory response due to the emotional
disorder than people who are not depressed.3 It should come as no
surprise that magnesium supplementation has a great effect on

In the final analysis there is no single medicine or nutritional
agent that has the power to both treat and prevent chronic
inflammatory conditions. Magnesium acts as a general cell tonic while
it reduces inflammation and systemic stress. Equally it is important
in overall energy (ATP) production, hormonal and enzyme production and
function which all reflect powerfully on the process of inflammation.

Other Natural Allopathic Solutions

Another new study reveals that marijuana relieves pain that
narcotics like morphine and OxyContin have hardly any effect on, and
could help ease suffering from illnesses such as multiple sclerosis
and diabetes. 4 Neuropathic pain is notoriously resistant to treatment
with conventional pain drugs. Even powerful and addictive narcotics
like morphine and OxyContin often provide little relief. This study
leaves no doubt that marijuana can safely ease this type of pain.

Cannabinoids reduced inflammation in the brain
and prevented cognitive decline. Cannabinoids have
also been shown to alleviate neuropathic pain.

Dr. Gregory T. Carter, Clinical Associate Professor of
Rehabilitation Medicine, University of Washington School of Medicine
says, “Marijuana is a complex substance containing over 60 different
forms of cannabinoids, the active ingredients. Cannabinoids are now
known to have the capacity for neuromodulation, via direct,
receptor-based mechanisms at numerous levels within the nervous
system. These have therapeutic properties that may be applicable to
the treatment of neurological disorders; including anti-oxidative,
neuroprotective, analgesic and anti-inflammatory actions;
immunomodulation, modulation of glial cells and tumor growth
regulation.6 Intracellular changes and altered signalling of the
neurons seems to be the principle effects of the cannabinoids in

Marijuana has strong anti-inflammatory effects. "This is why I
believe that people who used marijuana a few decades ago are much less
likely to develop any disease, such as Alzheimer's, that relies upon
the slow development of brain inflammation," said Wenk. The recent
discovery of an endogenous cannabinoid system with specific receptors
and ligands (a compound that activates a receptor and triggers its
characteristic response) has increased our understanding of the
actions of marijuana. Excessive inflammatory responses can emerge as a
potential danger for organisms’ health. Physiological balance between
pro- and anti-inflammatory processes constitutes an important feature
of responses against harmful events.


Turmeric (Curcuma longa, a member of the ginger family) is a
plant that, when ground to a yellowish powder, becomes the main
ingredient of curry powder, the well-known South Asian spice. The most
important chemical present in turmeric is Curcumin. This natural
product, a polyphenolic molecule, has numerous biological and
pharmacological properties. Chief among these are anticancer,
anti-inflammatory, antioxidant and antiamyloid effects. While the
health benefits of turmeric have been known for thousands of years
going back to its origins in ancient India, research into the medical
uses of curcumin as the active principle has been relatively recent,
spanning only a few decades. In a 2005 Wall Street Journal article
entitled, "Common Indian Spice Stirs Hope", medical research into the
health benefits of curcumin was described as "exploding".

According to the National Institutes of Health, curcumin is
currently being tested in almost a dozen human clinical trials as a
single therapeutic agent or in combination with other agents for the
treatment of conditions such as pancreatic cancer, colon cancer,
adenocarcinoma, precancerous gastrointestinal polyps, myelodysplastic
syndromes, Alzheimer's disease and psoriasis. Clinical trials of
curcumin for cancers of the digestive tract no doubt were inspired by
epidemiological data that show a decreased incidence of colorectal
cancer in ethnic groups that regularly ingest curry as part of their
normal diet.

Cancer prevention and therapy are the major focus of studies of
the medical uses of curcumin. The cancer chemoprevention effects of
topical curcumin application are well documented. Curcumin inhibits
chemical carcinogen-induced tumor initiation as well as tumor
promotion, which can be induced by such agents as the phorbol esters,
plant-derived chemicals known for their tumor promoting capabilities.
Thus, such studies have one plant-derived natural product (curcumin)
being used to counteract the adverse effects of a second natural
product (phorbol). Based on in vitro and in vivo findings, curcumin is
now being tested in human clinical trials as a cancer
chemopreventative agent. This is being done in addition to its use in
clinical studies as a treatment for the precancerous conditions noted
above. Curcumin has also been tested in vitro and in vivo as a cancer
chemotherapeutic agent, either by itself or in combination with other
anticancer agents. It is effective against such cancers as melanoma
and various carcinomas. It is believed that an important mechanism by
which curcumin inhibits or kills cancer cells involves the modulation
of various intracellular signal transduction pathways. Among the
current human clinical studies employing curcumin as a cancer
chemotherapeutic agent are trials of curcumin as a single agent or in
combination with gemcitabine for treating pancreatic and colorectal

One of the more recent findings with respect to curcumin's
anticancer properties is that it can selectively induce apoptosis
(programmed cell death) in cancer cells without harming normal cells.
Another recently reported anticancer property of curcumin is its
ability to inhibit NF-kappaB (NF-kB), a transcription factor that can
be overexpressed in many cancer cells, according to Dr. Dennis Liotta
of Davidson College. Of particular interest is the ability of curcumin
to inhibit cancer cell metastasis. Experiments conducted by Dr Bharat
Aggarwal and colleagues from the University of Texas MD Anderson
Cancer Center in Houston utilized a mouse model of cancer metastasis.
Groups of mice were treated either with the anticancer paclitaxel
(Taxol®), curcumin, or a combination of paclitaxel and curcumin. After
several weeks, it was found that the mice treated with curcumin and
the combination therapy had reductions in lung metastases of about 50%
and 75%, respectively, in comparison to an untreated control group. In
contrast, the paclitaxel-treated mouse group had only a 30% reduction
in metastases.

As with other antioxidants, curcumin may have utility in treating
Autism Spectrum Disorder, as patients may have increased sensitivity
to, or decreased protection from, damage caused by chemical free
radicals or UV radiation (oxidative stress). According to Dr. Woody R.
McGinnis, the use of antioxidants in these patients may markedly
reduce autistic behavior.

Curcumin may also have potential in combating Alzheimer's
disease. It has been found both in vitro and in vivo that curcumin can
inhibit the production and accumulation of beta-amyloid, a protein
that has been associated with the pathogenesis of Alzheimer's disease.
Curcumin's antiinflammatory properties may also play a role in its
potential utility as an Alzheimer's preventative or therapy. In fact,
researchers using a genetically altered mouse model of Alzheimer's
disease noted that not only can curcumin inhibit beta-amyloid
accumulation in the brain, it can also promote the reduction of
amyloid plaques that are characteristic of the disease.

Certain enzymes involved in the inflammatory response can be
inhibited by curcumin. Owing to its antiinflammatory properties,
curcumin in topical form has been used as a psoriasis treatment.
Additionally, curcumin topically applied to mouse skin has inhibited
chemically induced inflammation. Curcumin has also been investigated
in several studies as a topical wound-healing agent. The wound healing
benefits of curcumin may be related both to its antioxidant effects
(reduction of oxidative stress) as well as to its antiinflammatory

The anti-infective properties of curcumin are also of interest,
particularly the use of curcumin in the treatment of sexually
transmitted diseases. For example, curcumin was reported to be active
as an inhibitor of the bacterium Neisseria gonorrhoeae, the causative
agent in gonorrhea.

Mark Sircus Ac., OMD
Director International Medical Veritas Association